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Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
bleeding disorder Clinical ... INR • Normal aPTT ... VonWillebrand #Disease #Diagnosis
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... : Is the PT or APTT ... Prolonging the PT or APTT ... cause of Prolonged APTT ... #prolonged #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT/PTT ... organ damage Clinical ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT ... #Coagulation #diagnosis
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
Approach to Elevated aPTT ... - Differential Diagnosis ... Algorithm aPTT ... #Elevated #aPTT ... #differential #diagnosis
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
PT - Prolonged aPTT ... PT - Prolonged aPTT ... Coagulation #Abnormal #APTT ... Laboratory #Hematology #Diagnosis
Prolonged APTT - Diagnostic Algorithm

#Prolonged #APTT #PTT #abnormal #Diagnosis #Algorithm #hematology
Prolonged APTT - ... Diagnostic Algorithm ... #Prolonged #APTT ... #PTT #abnormal ... #Diagnosis #Algorithm
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... #Differential #Diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... Prolonged #Causes #diagnosis
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
INR), Prolonged PTT ... INR), Prolonged PTT ... (INR), Normal PTT ... • Prolonged PTT ... #Differential #Diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Prolonged PT and aPTT ... the PT and the aPTT ... #Abnormal #PT #aPTT ... Prolonged #Causes #diagnosis