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Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... dysfunction (25%) • Hepatic ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... INR < 2.3 - APTT
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... : Is the PT or APTT ... K Antagonists, Heparin ... Prolonging the PT or APTT ... cause of Prolonged APTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... unfractionated heparin ... cause e.g. heparin ... thrombin inhibitors, heparin
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #Abnormal #PT #aPTT
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH) UFH: • Advantages: -
Heparin - Unfractionated ... Heparin (UFH) vs ... Low-Molecular-Weight Heparin ... as compared to heparin ... available than aPTT
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
coagulation #coumadin #heparin ... vWF #thrombin #ptt
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm aPTT: Intrinsic / Final PT: Extrinsic / Final By
Approach to Elevated aPTT ... Diagnosis Algorithm aPTT ... #Elevated #aPTT
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
PT - Prolonged aPTT ... PT - Prolonged aPTT ... Coagulation #Abnormal #APTT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... Thromboplastin Time (PTT ... elevated in: • Heparin ... thematttsai #PT #PTT
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