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diagnosis differential clinical management hepatology algorithm causes pocus ultrasound hematology pathophysiology hepatic pharmacology treatment radiology signs cirrhosis comparison symptoms physicalexam
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... cause e.g. heparin ... thrombin inhibitors, heparin ... Reduced liver synthesis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... • Reduced liver
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... DIC • Severe Liver ... deficiency) • HIT: Heparin-PF4 ... 100mg/dL) - Heparin ... INR < 2.3 - APTT
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... : Is the PT or APTT ... K Antagonists, Heparin ... Prolonging the PT or APTT ... cause of Prolonged APTT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Thromboplastin Time (PTT ... inhibitor • Liver ... Thromboplastin Time (PTT ... elevated in: • Heparin ... thematttsai #PT #PTT
Heparin - Unfractionated Heparin (UFH) vs Low-Molecular-Weight Heparin (LMWH) UFH: • Advantages: -
Heparin - Unfractionated ... Heparin (UFH) vs ... Low-Molecular-Weight Heparin ... as compared to heparin ... available than aPTT
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
coagulation #coumadin #heparin ... vWF #thrombin #ptt
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm aPTT: Intrinsic / Final PT: Extrinsic / Final By
Approach to Elevated aPTT ... Diagnosis Algorithm aPTT ... #Elevated #aPTT
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
PT - Prolonged aPTT ... PT - Prolonged aPTT ... Coagulation #Abnormal #APTT
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