14 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PTT • Prolonged ... PT (INR), Normal ... PTT, Normal PT ... , Normal PT (INR ... #coagulation #disorders
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
the PT or APTT ... Is a Systemic Disease ... Prolonging the PT ... to identify the cause ... mixing #studies #PTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... discern these causes
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Prothrombin Time (PT ... Early liver disease ... #PT #aPTT #Prolonged
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... inherited bleeding disorder ... PT/INR • Normal ... aPTT (prolonged ... VonWillebrand #Disease
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... : INR/PT, aPTT(liver ... disease, decrease ... bypass), LFT (liver disease ... primary hematologic disorder
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... ) • aPTT is prolonged ... mixing study (aPTT ... mild cases) • ... PT/INR & von Willebrand
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... ristocetin • Normal ... platelet, PT, PTT ... Von Willebrand Disease ... #Platelet #disorders
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
Ketosis Disorders ... seen in several disease ... IVF or PO): The pt ... differential #diagnosis #management ... #endocrinology