36 results
diagnosis hematology treatment differential infectiousdiseases oncology syndrome classification criticalcare overview blood clinical disorders fusarium patient product reactions rheumatology shock workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... procedures - Infection ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... patients if the cause
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... /INR: ↑ • PTT: ... Treat primary cause ... INR < 2.3 - APTT ... #treatment #management
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... Chronic Management
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Diagnosis and Management ... are caused by members ... sensitivity (sn) 82% in pts ... sn lower in SOT pts ... IA #Diagnosis #Management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Neutropenia - recurrent infections ... and petechiae Causes ... Idiopathic • Infections ... • ↓ WBC • ↓ PLT ... hematology #diagnosis #management
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
be performed PT ... , PTT, and fibrinogen ... decrease in most cases ... result in severe anemia ... immune hemolytic anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... acute leukemia Management
Management of Jehovah's Witness patient in ICU Clarify which products may be used - Discuss
Management of Jehovah's ... document (e.g. some pts ... platelets, INR, PTT ... pro-actively if anemic ... #CriticalCare #Management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Infectious ... autoimmune hemolytic anemia ... and M panel Management ... DDX - Other causes ... hematology #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Cytopenia +++ (Plt ... Still disease, Infection ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management
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