27 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... procedures - Infection ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... #Differential #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
/PTT • Low plasma ... organ damage Clinical ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #Coagulation #diagnosis
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... and/or stress • Pts ... /other causes • ... IBD #Algorithm #diagnosis ... #management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... oncology #hematology #diagnosis ... #management
Invasive Aspergillus (IA) - Diagnosis and Management
Aspergillus is ubiquitous in nature. Most invasive infections are caused
Aspergillus (IA) - Diagnosis ... and Management ... are caused by members ... HIV/AIDS, CGD) Clinical ... #Management #treatment
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... intrinsic factor, IF) Clinical ... leukopenia and/or low pit ... consider other diagnosis ... #management #nutrition
Management of Jehovah's Witness patient in ICU 

Clarify which products may be used 
 - Discuss
Management of Jehovah's ... limit to mission-critical ... platelets, INR, PTT ... pro-actively if anemic ... Empiric folate and B12
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Cytopenia +++ (Plt ... Drugs, Unknown cause ... #management #treatment
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... and M panel Management ... DDX - Other causes ... #management
Graves Disease - Autoimmune Hyperthyroidism
Epidemiology: Most common cause of hyperthyroidism, Incidence peaks at 30-50
Diagnosis: 
1 )
Epidemiology: Most common cause ... peaks at 30-50 Diagnosis ... Clinical Presentation ... • Methimazole/PTU ... #management #endocrinology