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differential hematology treatment rheumatology neurology oncology classification criticalcare disease infectiousdiseases signs barre dermatology disorders guillain hemophagocytic hlh inflammatory lymphohistiocytosis overview
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... procedures - Infection ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... #Differential #Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
/PTT • Low plasma ... organ damage Clinical ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #Coagulation #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... Myelodysplastic #Syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... oncology #hematology #diagnosis ... #management
Invasive Aspergillus (IA) - Diagnosis and Management Aspergillus is ubiquitous in nature. Most invasive infections are caused
Aspergillus (IA) - Diagnosis ... and Management ... are caused by members ... HIV/AIDS, CGD) Clinical ... #Management #treatment
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Clinical Presentation ... • Symptoms of anemia ... anemia • Cold ... disease #hemolytic #anemia
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... SLE], AOSD) • Infection ... with leukopenia, anemia ... ↑ PTT • ↑ Fibrin ... #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Cytopenia +++ (Plt ... Drugs, Unknown cause ... #management #treatment
Graves Disease - Autoimmune Hyperthyroidism Epidemiology: Most common cause of hyperthyroidism, Incidence peaks at 30-50 Diagnosis: 1 )
Epidemiology: Most common cause ... peaks at 30-50 Diagnosis ... Clinical Presentation ... • Methimazole/PTU ... #management #endocrinology
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