19 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... or APTT Artifactually ... or APTT? ... to identify the cause ... of Prolonged APTT
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Causes of Prolonged ... PTTProlonged ... PTTProlonged ... PTTProlonged ... PTT, Normal PT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
PT and/or aPTT ... aPTT) 3. ... PT and aPTT 1. ... intravascular coagulation (DIC ... #aPTT #Prolonged
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #treatment #management
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... PT and aPTT If ... aPTT are both prolonged ... intravascularcoagulation (DIC ... #aPTT #Prolonged
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
/ABNORMAL PTT: ... Perform a PTT mixing ... prolonged after ... ABNORMAL PTT: Prolongation ... discern these causes
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... normal in mild cases
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... anti-MPO - Seen with PTU ... Discontinuation of causal ... Usual therapeutic management ... rheumatology #diagnosis #management
Postpartum Hemorrhage - Differential Diagnosis and Management 
Uterine Atony (80%) - Most PPH Will respond to
Diagnosis and Management ... epinephrine prn DIC ... CBC, fibrinogen, PT ... /PTT • Treat with ... Differential #Diagnosis #Management
Graves Disease - Autoimmune Hyperthyroidism
Epidemiology: Most common cause of hyperthyroidism, Incidence peaks at 30-50
Diagnosis: 
1 )
Epidemiology: Most common cause ... • Methimazole/PTU ... Hyperthyroidism #diagnosis #management ... #endocrinology