11 results
Coagulation Protein Tests (PT and PTT)

#Coagulation #Tests #PTT #algorithm #differential #pathophysiology
Coagulation Protein ... Tests (PT and PTT ... ) #Coagulation ... #Tests #PTT #algorithm ... #differential #pathophysiology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
/PTT • Low plasma ... protein C and S Pathophysiology ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... causes #treatment #management
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
and/or aPTT Prolonged ... typically prolong aPTT ... may prolong the aPTT ... and aPTT 1. ... (DIC) c.
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... (DIC) Platelet ... , aPTT: • Expected ... consumption of coagulation ... small vessels #DIC
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... intravascularcoagulation (DIC ... #aPTT #Prolonged ... differential #hematology #coagulation
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC ... Intravascular #Coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /NORMAL PTT: Suggests ... PTT suggests liver
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... thrombin #clot #PT ... #PTT #diagnosis ... models #hematology #pathophysiology
Management of Jehovah's Witness patient in ICU 

Clarify which products may be used 
 - Discuss
Management of Jehovah's ... document (e.g. some pts ... - Be aware of coagulation ... platelets, INR, PTT ... #CriticalCare #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... rapidly develops (DIC ... Cr, ↓Glucose, ↓PLT ... obgyn #diagnosis #management ... #pathophysiology