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diagnosis differential coagulation causes dic intravascular treatment abnormal algorithm disorders oncology product prolonged pt reactions rheumatology workup activation anemia aplastic
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... /PTT • Low plasma ... /INR: ↑ • PTT: ... INR < 2.3 - APTT ... #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... /aPTT MAHA likely ... /aPTT normal • ... Differential #Diagnosis #Management ... #Algorithm #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
and/or aPTT Prolonged ... typically prolong aPTT ... and aPTT 1. ... Disseminated intravascular ... #differential #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Scoring System for Disseminated ... , aPTT: • Expected ... acute-phase reactant Blood ... vessels #DIC #Disseminated ... Scoring #diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
and aPTT If the ... PT and the aPTT ... hemorrhage • Disseminated ... #aPTT #Prolonged ... #differential #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/ABNORMAL PTT: ... Perform a PTT mixing ... and the PTT suggests ... liver failure, disseminated ... Differential #Diagnosis #Hematology
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
prothrombin time (PT ... thromboplastin time (PTT ... A complete blood ... LaboratoryFindings #Disseminated
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
for decreased PLT ... plateletcount), peripheral blood ... , aPTT(liver disease ... or if a primary hematologic ... Causes #Workup #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... Chronic Management ... #treatment #hematology
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Diagnosis and Management ... PTH Independent ... Pancreatitis, Blood ... Hypocalcemia #Diagnosis #Management ... #endocrinology
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