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diagnosis differential coagulation abnormal disorders management treatment workup algorithm bleeding bruising dic disease disseminated evaluation hemophilia hemostasis intravascular mixing platelet
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PT (INR), Prolonged ... PT (INR), Prolonged ... PTT, Normal PT ... PTT, Normal PT
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Prolonging the PT ... to identify the cause ... of Prolonged APTT ... #hematology #evaluation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Time (PT) 1. ... PT and aPTT 1. ... #aPTT #Prolonged ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... aPTT are both prolonged ... #Abnormal #PT ... #aPTT #Prolonged
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
bleeding • Prolonged ... 2B) • Normal PT ... /INR • Normal ... aPTT (prolonged ... Disease #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... < 2.3 - APTT
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
in selected cases ... : INR/PT, aPTT(liver ... (CVID, WAS), (neurologic ... or if a primary hematologic ... #Workup #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/ABNORMAL PTT: ... /NORMAL PTT: Suggests ... prolonged after ... /ABNORMAL PTT: ... discern these causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... PT/INR & von Willebrand ... Management #treatment #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
be performed PT ... , PTT, and fibrinogen ... most cases; hemorrhage ... hematuria (without casts ... Diagnosis #Workup #Hematology
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