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diagnosis hematology differential coagulation abnormal pt disorders management treatment workup algorithm blanching bleeding bruise bruising dic disease disseminated ecchymosis evaluation
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
or APTT Artifactually ... or APTT? ... to identify the cause ... of Prolonged APTT ... mixing #studies #PTT
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... PTT • Prolonged ... PTT • Prolonged ... PTT, Normal PT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... aPTT) 3. ... the aPTT alone ... PT and aPTT 1. ... #aPTT #Prolonged
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... /INR: ↑ • PTT: ... Treat primary cause ... INR < 2.3 - APTT
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
bleeding • Prolonged ... platelet count (mild thrombocytopenia ... 2B) • Normal PT ... INR • Normal aPTT ... (prolonged if very
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Diagnosis for a Prolonged ... PT and aPTT If ... aPTT are both prolonged ... Causes include : ... #aPTT #Prolonged
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... practices that could cause ... : INR/PT, aPTT(liver ... patients if the cause ... of thrombocytopenia
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... prolonged after ... discern these causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... be performed PT ... , PTT, and fibrinogen ... decrease in most cases ... hematuria (without casts
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