7 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... or APTT Artifactually ... Prolonging the PT ... to identify the cause ... #prolonged #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... INR < 2.3 - APTT
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Mixing Study • ... • A mixing study ... PT and/or aPTT) ... #Study #diagnosis ... pathophysiology #hematology #laboratory
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... corrects with a mixing ... study (aPTT may ... normal in mild cases ... ) • PT/INR & von
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
== NORMAL PT ... /NORMAL PTT: • ... Perform a PTT mixing ... /ABNORMAL PTT: ... discern these causes
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity is the diagnostic ... available for rapid diagnosis ... be performed PT ... , PTT, and fibrinogen
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
IVF or PO): The pt ... ketoacidosis (DKA) - caused ... Glucosuria causes ... #differential #diagnosis ... #management #endocrinology