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diagnosis hematology differential algorithm rheumatology coagulation infectiousdiseases prolonged abnormal disorders hyperthyroidism infections table workup comparison disease dosing druginduced fusarium hemophilia
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Evaluate an Abnormal APTT ... Step 1: Is the PT ... Prolonging the PT ... or APTT? ... to identify the cause
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT • Prolonged ... PTT • Prolonged ... PTT, Normal PT ... Diagnosis #Algorithm #Causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Prothrombin Time (PT ... typically prolong PT ... antibody Prolonged PT ... #Abnormal #PT
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... /PTT • Low plasma ... Fibrinogen: ↓ • PT ... /INR: ↑ • PTT: ... #treatment #management
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the ... PT and the aPTT ... #Abnormal #PT ... #aPTT #Prolonged
Causes of AKI in Pregnancy - Differential Diagnosis Creatinine - Platelets - Transaminases - LDH - PT/PTT
Causes of AKI in ... Transaminases - LDH - PT ... /PTT - Schistocytes ... Differential #Diagnosis #Causes
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
2B) • Normal PT ... INR • Normal aPTT ... factor VIII) Treatment
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
/NORMAL PTT: • ... /ABNORMAL PTT: ... Perform a PTT mixing ... /ABNORMAL PTT: ... discern these causes
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