11 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Tranexamic Acid ... Indications and Pharmacology ... Post-partum, ICH/TBI, Hemoptysis ... TXA #Tranexamic #Acid ... #hematology
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Lactulose → ↑ Lactic Acid ... , Acetic Acid → ... #Lactulose #pharmacology ... mechanism #ammonia #hepatology
Role of Uric Acid in the Inflammation of Gout

Allopurinol, Febuxostat - Xanthine oxidase
Colchicine - Release of
Role of Uric Acid ... pathophysiology #pharmacology ... #rheumatology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
diff, BMP, uric acid ... ↑ Destruction (hemolysis ... Diagnosis #Algorithm #hematology
Nebulized Tranexamic Acid for acute treatment of stable hemoptysis 

- Mike O'Brien
@MikeEMPharmD

#Pharmacology #EBM #Management #Dosing #Pathophys
Nebulized Tranexamic Acid ... treatment of stable hemoptysis ... MikeEMPharmD #Pharmacology ... TranexamicAcid #Hemoptysis
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Elevated bile acids ... HELLP Syndrome (Hemolysis ... clinical features: Hemolysis ... Disease #Pregnancy #hepatology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
lactate NOT lactic acid ... coagulation and hemostasis ... NS #comparison #pharmacology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
limited) risk of hemolysis ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis
 - Chloroquine (Aralen)*
Due to Risk of Hemolysis ... G6PD #Deficiency #Hemolysis ... Differential #Diagnosis #Pharmacology ... #Hematology
Drug Induced Systemic Lupus Erythematosus
> 100 drugs have been associated with drug-induced SLE
High risk (>5%):
 •
Lisinopril, Nalidixic acid ... Ethosuximide, Valproic acid ... medications #drugs #pharmacology ... differential #diagnosis #rheumatology