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diagnosis differential causes blood extravascular intravascular management product reactions adverseeffects algorithm benefits calculation classification deficiency hcq hemolytic high hydroxychloroquine index
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Extravascular Hemolysis ... G6PD deficiency) ... EricsMedicalLectures/ #Hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Intravascular - Hemolysis ... anemia • ... malformations #Hemolysis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Enzyme Defects: G6PD ... Defects: Sickle cell anemia ... Urobilinogen #Hemolysis ... Differential #Diagnosis #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... , G6PD deficiency ... Production #Index #hematology
Medications to Avoid in Patients with G6PD Deficiency Due to Risk of Hemolysis - Chloroquine (Aralen)*
Patients with G6PD ... Due to Risk of Hemolysis ... #Deficiency #Hemolysis ... Differential #Diagnosis #Pharmacology ... #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
antibodies leading to hemolysis ... Hemolysis on labs ... , fever, minor hemolysis ... Hypocalcemia, Hyperkalemia ... products contain potassium
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
with caution] and G6PD ... limited) risk of hemolysis ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
antibodies leading to hemolysis ... Hemolysis on labs ... , fever, minor hemolysis ... Hypocalcemia, Hyperkalemia ... products contain potassium
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... leukocytosis, in vitro hemolysis ... ), sickle cell anemia ... amyloidosis, sickle cell anemia ... Diagnosis #High #Potassium
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