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diagnosis hematology differential algorithm hemolytic management antibody blood bloodcell classification gap globulin hodgkins lymphoma markers mcv mentzerindex microcytic microscopy morphology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(up to 100) = normocytic ... 95 (or 100) is macrocytic ... (BM) ablative disorders ... Algorithm #Diagnosis #Workup ... #Macrocytic
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(sometimes) Macrocytic ... Unstable hemoglobin disorders ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... hematology #microscopy #atlas
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Framework by MCV Microcytic ... Normocytic ( ... Spherocytosis, G6PD, PK, HbC ... - Extrinsic: Autoimmune ... Infections Macrocytic
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... Hemolytic Anemia ... : macrocytic > normocytic ... ↑ LDH • Anti-RBC ... Warm #Antibody #Autoimmune
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
RBC are produced ... fl), normocytic ... fl) & macrocytic ... involves production disorders ... that involves disorders
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Pseudo Pelger-Huet, Macrocytic ... anemia - ... bcr-able (+) ↑ WBC ... Amy Chung, MD, MSc
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... membrane disorder ... elliptocytosis, autoimmune ... Diagnosis #Algorithm #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... disorders Hodgkin ... Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Connective tissue disorders ... Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... Thalassemia, Sickle cell anemia
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