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diagnosis hematology differential algorithm oncology management rheumatology causes clinical diseases disorders leukemia lupus lymphocytic macrocytic morphology signs sle testing @dharsaty
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... myeloma Rouleaux: Chronic ... hematology #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... Atlas • Microcytic ... coagulopathy (DIC) #RBC ... #Morphology #Atlas
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... Red cell distribution ... for degree of anemia ... Algorithm #Diagnosis #Workup
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
• Lymphoid (ALL ... - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... bcr-able (+) ↑ WBC
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... of chronic inflammation ... deficiencies: Chronic ... , Intrinsic RBC ... defects (e.g. sickle cell
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #Chronic #Lymphocytic ... Leukemia #diagnosis #workup
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... cell; MMA = methylmalonic ... serum level for all ... of the initial work-up ... Homocysteine #Algorithm #Workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... Diagnosis #Algorithm #workup
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
Septic Arthritis ... Workup: arthrocentesis ... culture, Gram stain, cell ... parenteral Abx, Orthopedics ... Ciprofloxacin • Sickle Cell
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
rheumatic fever • Chronic ... Lyme), reactive arthritis ... Send for cell count ... hepatitis, herpes • Chronic ... rheumatology #approach #workup
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