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diagnosis hematology differential algorithm chronic lymphocytic management blood bloodcell cell classification dehydrogenase dermatology elevated erythematosus gap globulin hemeonc hemolytic hodgkins
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology ... Bite Cell RBC: G6PD ... Unstable hemoglobin disorders ... IgM associated lymphoma ... hematology #microscopy #atlas
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
, Auer rod • Lymphoid ... - Abnormal morphology ... Pelger-Huet, Macrocytic anemia ... (CLL) - CD38(new ... bcr-able (+) ↑ WBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
lymphoproliferative disorders ... • Neutropenia, anemia ... leukemia #CLL ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... in adults • Disorder ... 5) Symptoms of anemia ... lymphoma (Richter ... #oncology #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... other reproducible morphologic ... membrane disorder ... Diagnosis #Algorithm #workup
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... Workup: • Full ... classification #hematology #oncology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
concentrations in: RBCs ... • Hemolytic Anemias ... paralyses CNS Disorders ... Malignancy: • Lymphomas ... • Leukemias
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Leukemia • Idiopathic ... Workup: • Complete ... diagnosis #hematology #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Rare Disorder: ... general feeling of ill ... (malignancy), lymphoma ... - CBC may also ... #dermatology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
lymphoma • Evans ... lymphopenia, low PLT • Anemia ... titers > 1:80 • CBC ... cyclophosphamide) • Hodgkin lymphoma ... and leukemia •
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