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diagnosis hematology differential algorithm testing oncology causes hemolysis laboratory macrocytic morphology @dharsaty aafp acute aki antenatal arthritis bandemia bloodcell brucellosis
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... Iron-deficiency anemia ... coagulopathy (DIC) #RBC ... #Morphology #Atlas
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... hematology #microscopy #atlas
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (MCV): Average RBC ... for degree of anemia ... thecurbsiders podcast #Anemia ... Algorithm #Diagnosis #Workup
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... 2) External (RBC ... 3) Internal (RBC ... Defects: Sickle cell anemia ... Smear ↑ abnormal RBCs
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
of macrocytic anemia ... (RBC = red blood ... elevated, but anemia ... of the initial work-up ... Homocysteine #Algorithm #Workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... ARUPLabs #Hemolytic #Anemia ... Diagnosis #Algorithm #workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... result in severe anemia ... schistocytes, nucleated RBCs ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
elliptocytosis - RBC ... immune-complex hemolytic anemia ... Prosthetic heart valves
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Even with normal WBC ... appreciate the value ... 21% had normal WBC ... #CBC #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... changes), high MCV anemia ... disease), HBsAg/anti-HBc ... Diagnosis #Causes #Workup
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