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Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... small intestine), autoantibodies ... intrinsic factor, IF) Clinical ... B12 #Cobalamin #Deficiency
Autoimmune Gastritis - Pathophysiology Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
CD4+ T Cells, Autoantibodies ... Pathophysiology #b12 #deficiency
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Anti-Ro/SSA autoantibodies ... disease • Prolidase deficiency ... lymphoproliferative syndrome Clinical
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
to 50X ULN • Autoantibodies ... to 50X ULN • Autoantibodies ... : >50X ULN • Autoantibodies ... to 10x ULN • Autoantibodies
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Sclerosis Associated Autoantibodies ... Systemic #Sclerosis #Autoantibodies
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... to diagnosis deficiency ... levels will be deficient ... accumulate in B12 deficiency ... tests for B12 deficiency
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
C5-C9 Deficiency ... Pathogenesis and Clinical ... higher in C5-C9 deficiency ... infections • Clinical ... cell membranes -> Critical
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... RheumOnePagers #Autoantibodies
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Goodpasture's syndrome #Autoantibodies
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency Clinical Diagnosis - Caine Criteria (2 out of 4):
Thiamine (B1) Deficiency ... Clinical Diagnosis ... dysfunction - Dietary deficiency ... #Thiamine #B1 #Deficiency
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