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diagnosis anemia differential causes pancytopenia classification oncology approach macrocytic management mds mentzerindex microcytic myelodysplasia myelodysplastic normocytic rdw reticulocytes syndromes thrombocytes
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Differential Diagnosis Algorithm ... • Toxins • Aplastic ... deficiency: • B12 ... #Pancytopenia #Neutropenia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... -100): • Non-hemolytic ... : ACD, Aplastic ... Folate deficiency, B12 ... #Diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Differential Diagnosis Algorithm ... Reticulocytes, MCV ... Deficiency • B12 ... Deficiency • Aplastic ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Corpuscular Volume (MCV ... Differential Diagnosis Algorithm ... • Marrow Aplasia ... Bleed • Hemolysis ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Corpuscular Volume (MCV ... Differential Diagnosis Algorithm ... • Bleeding • Hemolysis ... (>100 fL) • B12 ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... - Parvovirus B19 ... - EBV - CMV ... • Parvovirus B19 ... Anemia #oncology #hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Differential Diagnosis Algorithm ... • 12-13 g/dL, ... /uL Initial Workup ... ↑ Destruction (hemolysis ... #hematology #workup
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(cell) volume (MCV ... acute blood loss, hemolysis ... (EPO), iron or B12 ... #Diagnosis #Workup ... #Hematology #Microcytic
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... Pancytopenia is a hematologic ... hemoglobin of less than 12 ... primarily seen as neutropenia ... /mean MCV) × 100
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Causes • Anemia • Aplastic ... Myeloproliferative Disease • Neutropenia ... Nutritional: vitamin B12 ... Syndromes #diagnosis #hematology
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