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diagnosis hematology algorithm cobalamin macrocytosis aafp atlas bloodcell decrease dm2 elevatedmcv elevation false folate folicacid hba1c hgba1c homocysteine increase laboratory
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
evaluation of macrocytic ... (RBC = red blood ... B12 deficiency ... deficiency. ... #Anemia #VitaminB12
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC ... RBCs in Rouleaux
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... , Iron deficiency ... (sometimes) Macrocytic ... RBC: Vitamin B12 ... #Morphology #differential
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin ... B12 deficiency, ... morphologic #mcv #differential ... #diagnosis #causes
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... turnover • Iron, B-12 ... , or folate deficiency ... glycosylation • Vitamin ... Diagnosis #DM2 #Differential
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... antagonists #VitaminB12 ... #cobalamin #differential
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
Vitamin B12 (Cobalamin ... ) Deficiency Etiology ... • Common Causes ... : • Worsening macrocytic ... • Labs: - CBC
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
common cytopenia: Macrocytic ... • Nutritional: vitamin ... B12 or folic acid ... deficiency • Exposure ... blood count with differential
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