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diagnosis hematology algorithm causes management oncology aplastic atlas bloodcell decrease dm2 elevatedmcv elevation hba1c hgba1c increase laboratory macrocytosis mentzerindex microscopy
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Infections Macrocytic ... , B12 deficiency ... Reticulocytosis, MDS ... #Differential #
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
- "Microcytic" ... - "Macrocytic" ... Megaloblastic: Vitamin ... B12 deficiency, ... #differential #
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Corpuscular Volume (MCV ... ) - Differential ... • Drugs Oval Macrocytes ... Neutrophils - Low RBC ... RBCs in Rouleaux
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... (sometimes) Macrocytic ... RBC: Vitamin B12 ... Liver Disease, MDS ... #Morphology #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
turnover • Iron, B-12 ... , or folate deficiency ... • Hemolytic anemia ... glycosylation • Vitamin ... Diagnosis #DM2 #Differential
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
RBC are produced ... anemia (MCV<80 ... & macrocytic anemia ... hemoglobin of less than 12 ... Satyendra Dhar MD
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
to repair DNA, as ... , GATA2 deficiency ... , CTLA4 deficiency ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
common cytopenia: Macrocytic ... • Nutritional: vitamin ... B12 or folic acid ... deficiency • Exposure ... blood count with differential
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... swollen, while in MS ... Predictive of MS ... Multiple sclerosis (MS ... : - Vitamin B12
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