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diagnosis hematology algorithm classification management neurology oncology acidosis aplastic approach crrt elevatedmcv elevation fatigue generalized ibd lactate lactic macrocytic macrocytosis
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... (>100 fL) • B12 ... #Differential #
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... #differential # ... diagnosis #causes
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Reticulocytes, MCV ... • B12/Folate ... Deficiency • Aplastic ... Diagnosis #Algorithm #Causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... • Dietary Deficiency ... and Folate Deficiency
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... to repair DNA, as ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness - Differential ... : CKD, ESRD • CV ... ILD, OSA, pHTN, Anemia ... #Diagnosis #causes ... #neurology
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... report dehydration as ... /other causes •
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... malignancy, or thiamine deficiency ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency ... Acidosis #Elevation #Differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Nutritional: vitamin B12 ... or folic acid deficiency ... treatments • Copper deficiency ... blood count with differential
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Check Vitamin B12 ... , HIV, Hep A/B/CMV ... • Nutritional Deficiency ... : - Vitamin B12 ... #differential
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