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diagnosis hematology algorithm acidosis aplastic approach creatine decrease dm2 elevated elevatedmcv false fatigue hba1c hgba1c ibd increase kinase laboratory lactate
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... (>100 fL) • B12 ... #MCV #Classification
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Reticulocytes, MCV ... • B12/Folate ... #Classification ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... #differential # ... diagnosis #causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... ) - Differential ... • Dietary Deficiency ... and Folate Deficiency
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Elevation (Pain ... viral (COVID19, CMV ... - Vit D/E deficiency ... #differential #
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... turnover • Iron, B-12 ... , or folate deficiency ... • Hemolytic anemia ... Diagnosis #DM2 #Differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... hematology #diagnosis #management
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
Crohn's > UC Anemia ... Receptor (sTfR) to differentiate ... restricted diet/deficiency ... /other causes • ... Algorithm #diagnosis #management
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... Acidosis - Differential ... 30mmHg) - Severe anemia ... #Differential # ... #typea #typeb #classification
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Check Vitamin B12 ... • Infectious causes ... • Nutritional Deficiency ... Myelitis #diagnosis #management ... #neurology #differential
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