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diagnosis hematology management algorithm cobalamin cord hepatology oncology spinal syndromes acidosis alkaline alp aplastic cirrhosis classification disorders elevatedmcv elevation hyophosphatasia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Dietary Deficiency ... - Low Serum B12 ... Myelodysplastic Syndromes
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) Low ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... morphologic #mcv #differential ... #diagnosis #causes
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... and Sjögren's syndrome ... #differential #
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... parasthesias, gait ... #Cobalamin #Deficiency
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... ) - Waddling gait ... Phosphatase: • Other causes
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... in Cirrhosis - Differential ... Diagnosis Framework LOW ... PRODUCTION • Vitamin B12 ... Destruction: Zieve's syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... may result from low
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Nutritional: vitamin B12 ... or folic acid deficiency ... treatments • Copper deficiency ... blood count with differential
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
result in permanent neurologic ... HIV) - Vitamin B12 ... , Copper deficiency ... unilateral) #SpinalCord ... #lesions #differential
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... of injury • Gait ... myelopathy - Vit B12 ... MCTD, Sjogren syndrome ... #spinal #cord #spinalcord
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