14 results
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Diagnosis Algorithm Low ... Renal Disease, Liver ... (>100 fL) • B12 ... #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... and petechiae Causes ... #management
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic ... ) - Waddling gait ... Phosphatase: • Other causes
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... intrinsic factor, IF) Clinical ... parasthesias, gait ... #diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
AnemiaAplastic ... Nutritional: vitamin B12 ... or folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
Dialyzer is rigid case ... efficiency daily ... dialysis): ~12 ... #Therapy #RRT #managment ... #nephrology #CRRT
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
of lactate as a clinical ... malignancy, or thiamine deficiency ... LV failure - Low ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Prolonged PT/PTT • Low ... organ damage Clinical ... Bleeding (64%) • Renal ... #treatment #management ... #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... recipients w/ IgA deficiency ... due to marrow aplasia ... Hypothermia: Due to low ... #hematology #reactions
Renal Replacement Therapy (RRT) Modalities

RRT Modalities in the ICU:
 • IHD (Intermittent HD):  3-5 hr
SLEDD (Sustained low ... efficiency daily ... dialysis): ~12 ... #Therapy #RRT #managment ... #nephrology #CRRT