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diagnosis differential algorithm causes lupus sle macrocytic mcv oncology signs systemic classification hepatology nutrition pancytopenia rbc workup alkaline alp aplastic
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Systemic lupus erythematosus ... consumption • Vitamin B12 ... • Folate deficiency ... Differential #Diagnosis #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
-100): • Non-hemolytic ... , CKD • Hemolytic ... Megaloblastic: Folate ... deficiency, B12 ... Differential #Diagnosis #hematology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
crisis • Severe B12 ... deficiency • Mechanical ... hemolytic anemia ... differential #diagnosis #hematology ... #hemolysis
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
and non-hematologic ... Toxins • Aplastic Anemia ... Myelodysplasia Nutritional deficiency ... : • B12/folate ... Algorithm #Causes #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Algorithm - Iron deficiency ... anemia - Anemia ... disease - Vitamin B12 ... and/or folate deficiency ... Underproduction #Algorithm #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
• Bleeding • Hemolysis ... (>100 fL) • B12 ... Deficiency • ... Folate Deficiency ... Algorithm #Causes #Hematology
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic Anemia ... • 812, Folate ... Deficiency • ... #Macrocytic #Anemia ... diagnosis #algorithm #hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... • Vitamin E - Haemolytic ... paraesthesiae • Folate ... gestation • Vitamin B12 ... diagnosis #signs #symptoms
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Macrocytic RBC: Vitamin B12 ... or Folate deficiency ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... differential #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Neutrophils - Low RBC Folate ... • Dietary Deficiency ... - Low Serum B12 ... and Folate Deficiency ... Algorithm #Causes #Hematology
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