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diagnosis differential hematology algorithm causes management nephrology workup classification erythematosus sle nutrition signs symptoms systemic vitaminb12 renal syndrome folate iron
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Diseases: • Systemic lupus ... consumption • Vitamin B12 ... • Folate deficiency
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Algorithm - Iron deficiency ... anemia - Anemia ... disease - Vitamin B12 ... and/or folate deficiency ... Underproduction #Algorithm #hematology
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic Anemia ... • 812, Folate ... Deficiency • ... #Macrocytic #Anemia ... diagnosis #algorithm #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... inflammation) • Iron deficiency ... Megaloblastic: Folate deficiency ... , B12 deficiency ... Differential #Diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80 fL) • Iron Deficiency ... (>100 fL) • B12 ... Deficiency • ... Folate Deficiency ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Dietary Deficiency ... - Low Serum B12 ... - Low Serum B12 ... and Folate Deficiency ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Thalassemia, Iron deficiency ... Macrocytic RBC: Vitamin B12 ... or Folate deficiency ... differential #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Microcytic" • Iron deficiency ... Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... diagnosis #causes #hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... • Thiamine B1 ... • Riboflavin B2 ... gestation • Vitamin B12 ... #Vitamins #Deficiency
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes • Iron Deficiency ... • B12/Folate ... Deficiency • Aplastic ... Anemia • Anemia ... Algorithm #Causes #Hematology
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