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diagnosis nephrology oncology apml b1 crrt differentiation diuresis emergencies encephalopathy excretion hematology hemeonc managment medications methotrexate modalities modes nutrition oncologic
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
Diagnosis and Management ... dysfunction (e.g. gait ... development of Korsakoff syndrome ... (chronic B1 deficiency ... #neurology #nutrition
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Regulating Renal ... irrigation • Management ... ; High-Ceiling Diuretics ... Tolvaptan) • Treatment ... #Diuresis #Nephrology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Attempt if high ... effusions, weight gain ... Anaphylaxis, Acute Renal ... Supportive Care: Diuresis ... APML #diagnosis #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
treat - Calcium > 12 ... → no immediate treatment ... Adjuncts: loop diuretics ... fever, weight gain ... , hypotension, renal
Methotrexate Renal Toxicity Prevention: • Alkalinize the urine, keep urine ph >7 • Start pre-treatment 12
12 hours prior ... alkalosis • Forced diuresis ... clearance but high ... #Toxicity #management ... #treatment #nephrology
Renal Replacement Therapy (RRT) - ICU One Pager Summary Indications (AIEOU): • A: Acidosis (usually severe metabolic)
refractory to diuretics ... daily dialysis): ~12 ... High clearance achieved ... #Therapy #RRT #managment ... #nephrology #CRRT
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