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diagnosis rheumatology dermatology management sle differential erythematosus systemic photo syndrome aclf activation acute adultonset autoantibodies cancer chronic cirrhosis comparison cutaneous
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar ... rash • SLE ... infection • Lyme ... lesions • Discoid lupus
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Neurological 12% ... Other auto-immune, Infectious ... diseases, Hematological ... #differential #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... Management #Summary #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... arthritis, Skin rash ... Diaqnoses: • Infectious ... diagnosis #management #treatment ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... fibromyalgia) • Infections ... Malignancy (e.g. hematologic ... lymphoproliferative syndrome Clinical ... vein thrombosis Hematologic
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
with or without treatment ... , but without treatment ... , the infection ... #Diagnosis #Clinical ... #Photo #Dermatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... 40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... Evolution: Chronic disease
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... months without treatment ... underlying liver disease ... Coagulation Failure Infections ... #gastroenterology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... Petechial or purpuric rash ... SJIA], systemic lupus ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Figure 4, page 12 ... in vasculitic diseases ... inflammation or infection ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
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