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diagnosis differential algorithm management chronic cll leukemia lymphocytic morphology aplastic bacilliformis bartonella bloodcell calculation cell classification fever hemeonc hodgkins index
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
: Vitamin B12 or ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... differential #diagnosis #hematology ... #microscopy #atlas
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... ) Morphology Atlas ... spherocytosis, Hemolytic ... #Morphology #Atlas ... #differential #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
, CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... Folate deficiency, B12 ... Non-megaloblastic: Liver disease ... Differential #Diagnosis #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... acute blood loss, hemolysis ... (EPO), iron or B12 ... Algorithm #Diagnosis #Workup ... #Hematology #Microcytic
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... loss), Vitamin B12 ... Chronic kidney disease ... RBC defects (e.g ... Production #Index #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Diagnosis #Algorithm #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... schistocytes, nucleated RBCs ... anemia Indirect ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... lysis → severe hemolytic ... anemia, jaundice ... TREATMENT: ​• Acute
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Parvovirus B19 ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... Treatment: ... #oncology #hematology
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