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diagnosis rheumatology oncology hemophagocytic lymphohistiocytosis sle chronic leukemia lymphocytic systemic activation algorithm arthritis classification comparison differential druginduced gastroenterology hemeonc hemochromatosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
: • Systemic lupus ... erythematosus ... • HLH • Paroxysmal ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... • Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... #Summary #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Treatment: • ... #rheumatology # ... management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
) Treatment Primary ... or autoimmune disease ... for refractory disease ... #Treatment #management ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... erythematosus ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Unknown cause Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... Low or absent NK cell ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... cells can indicate disease ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... • Immunologic Workup ... Erythematosus ( ... • Immunologic Workup ... Evolution: Chronic disease
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
) - Summary Overview ... chemotherapy for low-risk disease ... uw_IMresidency #CLL ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
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