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diagnosis hematology oncology differential leukemia management workup acute algorithm aplastic autoantibodies chronic cll disorders erythematosus hemeonc hemophagocytic hiv hlh lupus
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Megakaryopoiesis • B12 ... Autoimmune • ITP • SLE ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... pylori test (GI symptoms ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Workup #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Neurological 12% ... - Thrombocytopenia ... - Hemolytic anemia ... autoantibodies #signs #symptoms ... #differential #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
infections/fevers • Thrombocytopenia ... and petechiae Causes ... Treatment: ... • Improve the symptoms ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... platelet count (thrombocytopenia ... skin that are caused ... IDUS) • Immune Thrombocytopenia ... Nutritional: vitamin B12
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
enzymes ↑ • Mild anemia ... • Thrombocytopenia ... • New onset SLE ... detecting HIV for 10-12 ... antibody test) Treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... -> AML: Blast crises ... - infiltrates (anemia ... , thrombocytopenia ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... • Neutropenia, anemia ... , thrombocytopenia ... microglobulin Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Common Signs and Symptoms ... - Cytopenias (anemia ... , thrombocytopenia ... Diagnosis #Management #Hematology
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