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diagnosis management differential erythematosus syndrome hematology acidosis activation acute aplastic autoantibodies cerebritis classification cns comparison druginduced elevation endocarditis hiv infectiousdiseases
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... life-threatening • Treatment ... #lupus #Systemic ... Management #Summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... autoantibodies that will cause ... #SLE #CNS #neurology ... #rheumatology #
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Neurological 12% ... - Hemolytic anemia ... #Systemic #Lupus ... #differential #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... Discontinuation of causal ... months to years) Systemic ... life-threatening • Treatment ... #table #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
[SLE], AOSD) • ... with leukopenia, anemia ... Triglycerides • ↑ Lactate ... Treatment: • Corticosteroids ... #Rheumatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... again we might see ... Causes of Lactate ... of Circulatory System ... 30mmHg) - Severe anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... propylthiouracil) - β-lactam ... - Parvovirus B19 ... Treatment: ... #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Cryoglobulinemia (4%-12% ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Central nervous system ... enzymes ↑ • Mild anemia ... • New onset SLE ... detecting HIV for 10-12 ... antibody test) Treatment
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
• Autoimmune (SLE ... Septic emboli cause ... Leukocytosis, anemia ... hematuria, + RF Treatment ... Differential #Diagnosis #cardiology
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