23 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... old, ~10,000 new cases ... cytopenias (usually anemia ... #hematology #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... Diagnosis #Algorithm #Causes ... #Hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Nutritional: vitamin B12 ... factor (GCSF) treatments ... treatment (examples ... #hematology #oncology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Megaloblastic: Vitamin B12 ... Hypothyroidism, Myelodysplastic ... syndrome - Dr ... differential #diagnosis #causes ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... and petechiae Causes ... CMV) • Epstein-Barr ... Treatment: ... #oncology #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... Abnormalities: macrocytic anemia ... multiple myeloma, myelodysplastic ... polyarteritis nodosa (12%
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Epidemiology: • 1-2 cases ... Clinical Features ... #management #treatment ... #neurology
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... transplantation CLINICAL ... and cauda equina TREATMENT ... #Syndrome #diagnosis
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... Incubation period: 3-12 ... severe hemolytic anemia ... TREATMENT: ​• Acute
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... Puncture, EEG Treatment ... #rheumatology #