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management differential hematology syndrome erythematosus joint symptoms systemic arthritis classification dermatology leukemia msk neurology vasculitis workup activation algorithm ana antibodies
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
infection Malar ... infection • Lyme ... lesions • Discoid lupus ... #differential #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Neurological 12% ... Other auto-immune, Infectious ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... : Lupus (SLE), Systemic ... Lymphoproliferative Disorders, Infection ... ANA #patterns #rheumatology ... #diagnosis #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Framework Non-Infectious ... (RA), Systemic lupus ... erythematosus (SLE ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... noninflammatory Signs ... • Parvovirus B19 ... arthritis • SLE ... #MSK #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... fibromyalgia) • Infections ... Arthritis: • Joint pain ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... erythematosus [SLE ... ], AOSD) • Infection ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint Pain ... - Diagnostic Framework ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... : HLH signs and ... : • Infection ... agent are the main ... #hematology
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