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diagnosis management table algorithm classification latenttb syndrome tb tuberculosis anemia antiarrhythmics aplastic apml chemotherapy chf classes clinical criticalcare cyp3a4 decisionaid
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
lead to severe bleeding ... management #algorithm #pharmacology ... #treatment #medications ... #decisionaid #cardiology ... #hematology #warfarin
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... Tyrosine Kinase activity ... fever, joint pain, bleeding ... #Leukemia #Hematology ... #Oncology #Diagnosis
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
macrophages and T cells ... involvement - seeding ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
interactions) Cancer-treatment ... DOACs thereby leading ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
macrophages and T cells ... involvement - seeding ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... Imaging: CXR- pulmonary ... diagnosis #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... number of CD34+ cells ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... node and AV node activity ... inotropy) ACCP Cardiology ... Antiarrhythmics #Pharmacology ... pathophysiology #phases #cardiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... factor (GCSF) treatments ... Syndromes #diagnosis #hematology ... #oncology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... Simultaneous clotting and bleeding ... interventional radiology ... “big & sticky” cells ... renal failure, pulmonary
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