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diagnosis management differential oncology syndrome algorithm infectiousdiseases rheumatology signs table acquired aids anemia aplastic apml associated cancer cap cardiology clinical
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... - pulmonary opacities ... Diagnosis: >3 symptoms ... sepsis), PE, DAH, CHF ... diagnosis #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
lymphadenopathy CML Findings ... develop leukostasis syndrome ... manifestations, hypoxia, CXR ... • Tumor lysis syndrome ... #Leukemia #Hematology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Pathogenesis and clinical findings ... PO4& Mg prior to feeding ... overload -> - CHF ... - Pulmonary ... pathophysiology #symptoms
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... , dyspnea, +/- CXR ... Lysis of tumor cells ... diagnosis #management #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
ARDS to explain symptoms ... : Age>60, CKD, CHF ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... unusual bruising or bleeding ... are caused by bleeding ... factors (examples: G-CSF ... #diagnosis #hematology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
or serologies + symptoms ... FINDINGS: • AAV ... capillaritis leading ... of DAH) RENAL FINDINGS ... diagnosis #management #treatment
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... Paradoxical spontaneous bleeding ... thrombophlebitis, pulmonary ... Antiphospholipid syndrome ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... aplastic anemia Treatment ... • Improve the symptoms ... Anemia #oncology #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
): - Hematologic ... Simultaneous clotting and bleeding ... interventional radiology ... “big & sticky” cells ... renal failure, pulmonary
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