11 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Symptoms: • Malaise, bleeding ... develop leukostasis syndrome ... Fibrinolysis & DIC • Tumor ... lysis syndrome: ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... transformation to acute leukemia ... #treatment #hematology ... #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... lymphoma & Acute leukemia ... #Lysis #Syndrome ... #TLS #oncology ... #management #UricAcid
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
• Most common leukemia ... patients with minimal tumor ... lymphocytes, smudge cells ... #oncology #hematology ... hemeonc #diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... diagnosis #hematology #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
ecchymoses, mucosal bleeding ... virus (EBV) • Leukemia ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... hematology #diagnosis #management
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS (tumor-lysis ... Simultaneous clotting and bleeding ... interventional radiology ... Usually myeloid leukemias ... renal failure, pulmonary
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... APML #diagnosis #management ... #hematology #oncology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Immunosuppression • Tumor ... involvement - seeding ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Immunosuppression • Tumor ... involvement - seeding ... Tuberculosis Treatment ... TB #Diagnosis #Management ... #Treatment #ActiveTB