31 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... arthritis, Skin rash ... fraction < 20% Differential ... #diagnosis #management ... #treatment #rheumatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... months without treatment ... disease, liver ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... • NASH, Chronic ... RBC (hemolysis, bleeding ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Clinical features ... the spleen or liver ... Hepatosplenomegaly, cytopenias(bleeding ... involvement Differential ... #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... disease: > 2 ... • NASH, Chronic ... RBC (hemolysis, bleeding ... chemistry #diagnosis #differential
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... DIC • Severe Liver ... Disease: - Impaired ... Treatment: ... #management #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... Manifestations: Malar rash ... life-threatening • Treatment ... Evolution: Chronic disease ... #Summary #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
/splenomegaly, liver ... Treatment - Mild ... : NSAIDS Treatment ... AOSD #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
purpura to mucosal bleeding ... Petechial or purpuric rash ... thrombocytopenia • Liver ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
ducts, commonly leading ... disease management ... remain subject to clinical ... Cholangitis #diagnosis #management ... #summary #Hepatology