13 results
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... telomeropathy Cancer ... #Differential # ... Diagnosis #Hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
neutropenia • Mucosal bleeding ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... diagnosis #management #treatment ... #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Lymphadenopathy - Differential ... Leukemia - History of Bleeding ... Lymphoblastic Leukemia (Pancytopenia ... Algorithm #Causes #Hematology ... #Oncology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
incidental DVT or PE in cancer ... thrombosis in cancer ... at high risk of bleeding ... Anticoagulation #Management #Hematology ... #Oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Diagnosis #Algorithm #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
bone marrow + pancytopenia ... ecchymoses, mucosal bleeding ... • Peripheral Pancytopenia ... Treatment: ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... - History of bleeding ... changes), high MCV anemia ... ITP, unexplained pancytopenia ... Causes #Workup #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... DOACs thereby leading ... metabolization leading ... #Chemotherapy #Oncology ... #Hematology #Interactions
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
night sweats, bleeding ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology