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diagnosis algorithm oncology pancytopenia workup causes deficiency b12 chronic cll infections infectiousdiseases iron leukemia lymphocytic management mds mycobacteria myelodysplasia myelodysplastic
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Pregnancy, EPO treatment ... Loss (without anaemia ... Hookworm infection, Bleeding ... Iron #Deficiency #differential ... diagnosis #causes #nutrition
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
HLH syndrome 5. ... Drugs Nutritional ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... Diagnosis #Algorithm #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... ecchymoses, mucosal bleeding ... anemia Treatment ... #hematology #diagnosis
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
HLH syndrome 5 ... Drugs Nutritional ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... Diagnosis #Algorithm #Hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... telomeropathy Cancer ... Antibody-mediated hemolysis Nutritional ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Kawasaki, Nephrotic syndrome
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are caused by bleeding ... • Aplastic Anemia ... Platelet Disorders • Nutritional ... blood count with differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment ... workup #oncology #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Neutropenia - Differential ... hypertension and/or drug treatment ... Megaloblastic anemia-rare ... white blood cell aplasia ... diagnosis #causes #hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
: • Syndrome of ... disease, alcohol, cancer ... Hematologic malignancy ... Bone Marrow - Anemia ... NTM #Infections #differential
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