14 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Tranexamic Acid ... Indications and Pharmacology ... angioedema) • Metabolism ... of Excretion: Urine ... Hemoptysis, GI Bleeding
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
poisoning Normal acid-base ... the indicated causes ... and potassium acid ... #Algorithm #nephrology ... #differential #
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
electrolytes, urea, uric acid ... osmolarity If cause ... investigations depending on clinical ... #Diagnosis #nephrology ... #causes
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... consequence of fatty acid ... (FA) metabolism ... Disorders #ketones #differential ... #diagnosis #management
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... aminoglycosides) • Muscles: Acid ... Malnutrition, Metabolic ... #differential # ... diagnosis #neurology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
fetal free fatty acid ... metabolism products ... metabolism accumulate ... = nonspecific (nausea ... infiltration) Differential
Nephrolithiasis: Medications Associated with Renal Stones
 • Hypercalciuria: Furosemide, Topiramate, Vitamin D/Calcium, Glucocorticoids
 • Precipitation of
Precipitation of drug/metabolite ... uric acid: Probenecid ... Renal #Stones #pharmacology ... #differential # ... diagnosis #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... Summary Causes ... Heat stroke - Metabolic ... Dermatomyositis Clinical ... #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
resistance • Metabolic ... irrigation • Management ... Bumetanide, Ethacrynic acid ... Kidney stones caused ... #Pharmacology #
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death Common Clinical ... depressed) • Renal: metabolic ... Classification #diagnosis #management ... #criticalcare #differential ... #causes #classification