14 results
diagnosis differential hepatology rheumatology anemia hemolytic liver management algorithm antibody bariatric bypass chemistry cirrhosis classification common complications congenital cryofibrinogenemia cryoglobulinemia
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... haptoglobin ↑ indirect bilirubin ... 2) LOOK FOR a cause ... Warm #Antibody #Autoimmune ... management #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... uremic syndrome ... Extravascular #Causes ... differential #diagnosis #hematology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Inherited Non-hemolytic ... without evidence of hemolysis ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Drug-associated, PCH, Evans Syndrome ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... , bleeding, hematoma
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... Myelodysplastic syndrome ... #hematology #secondary
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
: RBC (hemolysis ... , bleeding, hematoma ... • Gilbert's syndrome ... • Hemolysis ... #differential #Hepatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... • They can cause ... Cryoglobulins Cause ... infection • Autoimmune ... Often Secondary to Autoimmune
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... Destruction: Zieve's syndrome ... Spur cell anemia, Autoimmune ... hemolytic anemia ... , Hemolysis related
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
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