13 results
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
week • Direct bilirubin ... Elevation: • Bilirubin ... RBC (hemolysis, bleeding ... • Gilbert's syndrome ... #differential #Hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... necrosis HELLP Syndrome ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... diagnosis #icp #HELLP #AFLP
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
TTP/HUS, HELLP Syndrome ... of Pregnancy (AFLP ... ) Three syndromes ... child * Severe cases ... #obstetrics #hematology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... Diagnosis #Algorithm #gastroenterology ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia 

== Disorders of Conjugation ==
Gilbert Syndrome:
 • 5-10% of the population
hyperbilirubinemia syndrome ... of hemolysis or liver ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... Hemolysis, Elevated Liver ... child * Severe cases ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... function: INR, bilirubin ... • Budd Chiari syndrome ... sarcoidosis) • Liver ... #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
purpura to mucosal bleeding ... thrombocytopenia • Liver ... ↑ AST ↑ ALT ↑ bilirubin ... Diagnosis #Management #Hematology ... #Rheumatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... slightly elevated • Bilirubin ... obstruction • ALP ... or higher • Liver