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diagnosis differential management oncology workup algorithm classification hydroxychloroquine pharmacology product reactions sle treatment vasculitis adverseeffects anemia aplastic approach arthritis benefits
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
half-life = 40 days ([HCQI ... intake) • Target blood ... Insufficient blood ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... plateletcount), peripheral blood ... PT, aPTT(liver disease ... #Workup #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... inflammation, leading ... thrombosis and/or blood-brain ... CNS #neurology #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... Benefits: ↓ Disease ... other medications leading ... Hydroxychloroquine #hcq ... #sideeffects #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... • Severe Liver Disease ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Von Willebrand disease ... inhibitor and lupus ... Willebrand syndrome • Lupus ... discern these causes ... Differential #Diagnosis #Hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... cause of transfusion ... more likely to cause ... Borrellia (Lyme disease ... diagnosis #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
which can plug blood ... Paradoxical spontaneous bleeding ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... cause of transfusion ... more likely to cause ... Borrellia (Lyme disease ... diagnosis #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... extramedullary disease ... -> AML: Blast crises ... #Leukemia #Hematology
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