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diagnosis management oncology disease algorithm chronic hemophagocytic hlh lymphohistiocytosis workup activation anemia anticoagulation aplastic bariatric behcet bypass calculators cancer capillary
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Hypereosinophilic Syndrome ... • Clinically ... suspect underlying hematologic ... Diagnosis and Treatment ... #HES #Hematology
A non-subtle example of true Sezary syndrome. Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... disorder Clinical ... • Prolonged bleeding ... factor VIII) Treatment ... Disease #Diagnosis #Hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
Bleeding risk calculators ... validated for VTE treatment ... studies suggest net clinical ... with very high bleeding ... Anticoagulation #Factors #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... inflammation, leading ... Puncture, EEG Treatment ... CNS #neurology #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... organ damage Clinical ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Susac Syndrome - Clinical Triad - Central nervous system dysfunction - Branch retinal artery occlusion -
Susac Syndrome - ... Clinical Triad ... arterioles - Treatment ... David #Susac #Syndrome ... Diagnosis #Management #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... ecchymoses, mucosal bleeding ... aplastic anemia Treatment ... Anemia #oncology #hematology
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