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diagnosis blood pathology anemia leukemia microscopy oncology rouleaux coagulation disseminated intravascular product reactions treatment activation analysis aplastic causes cerebritis chronic
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
Rouleaux formation ... #Rouleaux #formation ... gammopathy #MGUS #Clinical ... #Pathology #Hematology ... #Smear
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
extensive rouleaux formation ... leukemia #rouleaux #formation ... #Clinical #Smear ... #Hematology #Pathology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... • Peripheral smear ... significant fibrin clot formation ... causes #treatment #management ... #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood Smear ... DIC, TTP, HUS) ... Peripheral #Blood #Smear ... #Analysis #hematology ... interpretation #clinical
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... accelerate thrombin formation ... reactant Blood smear ... small vessels #DIC ... Scoring #diagnosis #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... arrow) Peripheral smear ... hemolytic #anemia #Hematology ... #Pathology #Smear
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Thrombocytopenic Purpura Clinical ... Menorrhagia • GI bleeding ... Intracranial hemorrhage Management ... only for severe bleeding ... Diagnosis #Overview #Hematology
Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on
from “Rouleaux formation ... #Clinical #Pathology ... #Blood #Smear # ... Microscopy #Rouleaux #Formation ... #Hematology
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
pain, abnormal bleeding ... ) • Rouleaux formations ... peripheral blood smear ... Electrophoresis #SPEP #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... • Peripheral smear ... • Significant bleeding ... Fibrinolysis & DIC ... #Leukemia #Hematology
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